Oxidative damage and plasma antioxidants in cerebrovascular accident.

Random blood samples were col lected from the stroke patients meeting following cr i te r ia : In t ra cerebra l haemorrhage or cerebra l thrombos is d iagnosed by bra in CT; No blood in vent r icu lar sys tem or subarachnoid space on bra in CT; No evidence of organic heart disease or other poss ib le cause o f cerebra l embol i sm. Cigare t te smokers and a lcohol ics were excluded. The study population consisted of 46 patients with CVA, and 50 age and sex matched normal sub jec t s. 46 pat ients included 16 cases (males 10, females 6) of intracerebral hemorrhage and 30 cases of cerebral thrombosis (males 21, females 9). All these patients were in an acute phase of stroke. Thus, the study included 3 groups hemor rhagic s t roke, thrombot ic s t roke ( i schemic s t roke) and contro l g roup. 12 i schemic s t roke pa t ients who rece ived aspirin (150 mg/day) or clopidogrel (75 mg/ day) or warfarin (5 mg/day) were considered for follow up studies, after one month of t rea tment .